Associazione Lyme Italia e Coinfezioni
Malattia di Lyme
Pubblicazioni Scientifiche
BIOFILM e FORME PERSISTENTI
- Feng, J, Zhang, Y. et al. Stationary Phase Persister/Biofilm Microcolony of Borrelia burgdorferi Causes More Severe Disease in a Mouse Model of Lyme Arthritis: Implications for Understand-ing Persistence, Post-Treatment Lyme Disease Syndrome (PTLDS), and Treatment Failure. Pub-lished in Discovery Medicine on March 28, 2019
https://pubmed.ncbi.nlm.nih.gov/30946803/ - Horowitz, R.I.; Freeman, P.R. Precision Medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1. International Journal of General Medicine 2019:12 101–119
https://www.dovepress.com/precision-medicine-retrospective-chart-review-and-data-analysis-of- 200-peer-reviewed-article-IJGM - Marianne J Middelveen, Katherine R Filush, Cheryl Bandoski, Rumanah S Kasliwala, Anthony Melillo, Raphael B Stricker, Eva Sapi. 2019 May 17;7(2):70 Mixed Borrelia burgdorferi and Helicobacter pylori Biofilms in Morgellons Disease Dermatological SpecimensSpecimens
https://www.researchgate.net/publication/333182225_Mixed_Borrelia_burgdorferi_and_Helicobacter_pylori_Biofilms_in_Morgellons_Disease_Dermatological_Specimens - Eva Sapi, Rumanah S. Kasliwala, Hebo Ismail, Jason P. Torres, Michael Oldakowski, Sarah Markland, Gauri Gaur, Anthony Melillo, Klaus Eisendle, Kenneth B. Liegner, Jenny Libien, and James E. Goldman Antibiotics (Basel). 2019 Dec; 8(4): 183 The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme Disease
https://www.researchgate.net/publication/336458826_The_Long- Term_Persistence_of_Borrelia_burgdorferi_Antigens_and_DNA_in_the_Tissues_of_a_Patient_with_Lyme_Disease - Rudenko, N. et al. Metamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persisters. Parasites Vectors (2019) 12:237.
https://doi.org/10.1186/s13071-019-3495-7 - Jie Feng, Tingting Li, Rebecca Yee Yuting Yuan, Chunxiang Bai1, Menghua Cai1,Wanliang Shi1, Monica Embers, Cory Brayton, Harumi Saeki, Kathleen Gabrielson4, Ying Zhang 2019 Mar;27(148):125-138 Biofilms and stationary phase persister forms of Bb are resistant to commonly used antibiotics and can explain in part persistent symptoms.
http://www.discoverymedicine.com/Jie-Feng/2019/03/persister-biofilm-microcolony-borrelia-burgdorferi-causes-severe-lyme-arthritis-in-mouse- model/?fbclid=IwAR0N5zOSLW5mfrjuUijKzxslqcy_9PwEL2PQExoF6sc9fM3YtkLxxDUt8uE - Lacout A, Dacher V, El Hajjam M, Marcy PY, Perronne C. Biofilms busters to improve the detection of Borrelia using PCR. Med Hypotheses. 2018;112:4-6.
https://www.ncbi.nlm.nih.gov/pubmed/29447935 - .Enea Gino Di Domenico, Ilaria Cavallo,Valentina Bordignon, Giovanna D'Agosto, Martina Pontone, Elisabetta Trento, Maria Teresa Gallo, Grazia Prignano, Fulvia Pimpinelli, Luigi Toma, and Fabrizio Ensoli The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis Front Neurol. 2018; 9: 1048.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287027/ - Jie Feng, Shuo Zhang, Wanliang Shi, and Ying Zhang. Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Microcolony B. burgdorferi Persisters Which Are Sterilized by Daptomycin/ Doxycycline/Cefuroxime without Pulse Dosing Front Microbiol. 2016; 7: 1744.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095124/ - Horowitz RI, Freeman PR. The use of dapsone as a novel “persister” drug in the treatment of chronic Lyme disease/post treatment Lyme disease syndrome. J Clin Exp Dermatol Res. 2016;7:345.
https://www.longdom.org/open-access/the-use-of-dapsone-as-a-novel-persister-drug-in-the-treatment-of-chroniclyme-diseasepost-treatment-lyme-disease-syndrome-2155-9554-1000345.pdf - Horowitz RI, Freeman PR Are Mycobacterium Drugs Effective for Treatment Resistant Lyme Disease, Tick-Borne Co-Infections, and Autoimmune Disease? JSM Arthritis(2016) 1(2): 1008
https://www.researchgate.net/publication/324978706_Are_Mycobacterium_Drugs_Effective_for_Treatment_Resistant_Lyme_Disease_Tick-Borne_Co-Infections_and_Autoimmune_Disease - E. Sapi, A. Poruri, K. Balasumbramnian, J.S. Maghsoudlou European Journal of Microbiology and Immunology 6(1):1-16February 2016 Evidence of In Vivo Existence of Borrelia Biofilm in Borrelia Lymphocytomas
https://www.researchgate.net/publication/293807237_Evidence_of_In_Vivo_Existence_of_Borrelia_Biofilm_in_Borrelial_Lymphocytomas - Jie Feng, Wanliang Shi, Shuo Zhang, Ying Zhang. Persister Mechanisms in Borrelia Burgdorferi: Implications for Improved Intervention Emerg Microbes Infect. 2015 Aug;4(8):e51.
https://pubmed.ncbi.nlm.nih.gov/26421273/ - John R Caskey, Monica E Embers. Persister Development by Borrelia Burgdorferi Populations In Vitro Antimicrob Agents Chemother. 2015 Oct;59(10):6288-95
https://pubmed.ncbi.nlm.nih.gov/26248368/ - Zhang, Y (2015) Drug Combinations against Borrelia burgdorferi Persisters In Vitro: Eradication Achieved by Using Daptomycin, Cefoperazone and Doxycycline. PLoS ONE 10(3): e0117207
https://www.ncbi.nlm.nih.gov/pubmed/25806811Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection. - Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection. Zhang, Y. Emerging Microbes and Infections (2015) 4, e31
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176177/ - Biofilm formation by Borrelia sensu lato FEMS Microbiology Letters 362(15) July 2015
https://www.researchgate.net/publication/280388181_Biofilm_formation_by_Borrelia_sensu_lato - Persisters, persistent infections and the Yin–Yang model, Ying Zhang; Emerging Microbes and Infections (2014) 3, e3;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913823/ - Lewis K. Persister cells, dormancy and infectious disease. Nature Rev Microbiol. 2007; 5 (1): 48–56. doi:10.1038/nrmicro1557. PMID 17143318.
https://www.ncbi.nlm.nih.gov/pubmed/17143318 - Jie Feng, Megan Weitner, Wanliang Shi, Shuo Zhang, David Sullivan and Ying Zhang. Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library Antibiotics 2015, 4, 397-410; doi:10.3390/antibiotics4030397
https://francelyme.fr/site/mediatiques/wp-content/uploads/sites/5/2013/01/antibiotics-04-00397.pdf
BORRELIA MIYAMOTOI
- Borrelia miyamotoi: 43 CASES Diagnosed in France by Real-Time PCR in Patients with Persistent Polymorphic Signs and Symptoms
https://www.frontiersin.org/articles/10.3389/fmed.2020.00055/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=& journalName=Frontiers_in_Medicine&id=498798 - J Koetsveld, A E Platonov , K Kuleshov , A Wagemakers , D Hoornstra , W Ang , S Szekeres , G L A van Duijvendijk, E Fikrig, M E Embers, H Sprong , J W Hovius Borrelia Miyamotoi Infection Leads to Cross-Reactive Antibodies to the C6 Peptide in Mice and Men Clin Microbiol Infect. 2020 Apr;26(4):513.e1-513.e6.
https://pubmed.ncbi.nlm.nih.gov/31404672/ - Karan L, Makenov M, Kolyasnikova N, Stukolova M, Toporkova M, Olenkova O. Dynamics of spirochetemia and early PCR detection of Borrelia miyamotoi. Emerg Infect Dis. (2018) 24:860–7. doi: 10.3201/eid2405.170829
https://wwwnc.cdc.gov/eid/article/24/5/17-0829_article - Fiecek B, Chmielewski T, Tylewska-Wierzbanowska S. Borrelia miyamotoi - new etiologic agent of neuroborreliosis? Przegl Epidemiol. 2017;71(4):531-8
https://www.ncbi.nlm.nih.gov/pubmed/29415531 - Wagemakers A, Jahfari S, de Wever B, Spanjaard L, Starink MV, de Vries HJC, et al. Borrelia miyamotoi in vectors and hosts in the Netherlands. Ticks Tick Borne Dis. (2017) 8:370–4. doi: 10.1016/j.ttbdis.2016.12.012
https://www.sciencedirect.com/science/article/pii/S1877959X1630293X?via%3Dihub - Stone BL, Brissette CA. Host immune evasion by Lyme and relapsing fever Borreliae: Findings to lead future studies for Borrelia miyamotoi. Front Immunol.(2017) 8:12. doi: 10.3389/fimmu.2017.00012
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00012/full - Röttgerding F, Wagemakers A, Koetsveld J, Fingerle V, Kirschfink M, Hovius JW, et al. Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties. Sci Rep. (2017) 7:303. doi: 10.1038/s41598-017-00412-4
https://www.nature.com/articles/s41598-017-00412-4 - Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clin Microbiol Infect. (2015) 21:631–9. doi: 10.1016/j.cmi.2015.02.006
- https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X (15)00294-3/fulltext
- Reiter M, Schötta AM, Müller A, Stockinger H, Stanek G. A newly established real-time PCR for detection of Borrelia miyamotoi in Ixodes ricinus ticks. Ticks Tick Borne Dis. (2015) 6:303–8. doi: 10.1016/j.ttbdis.2015.02.002
https://www.sciencedirect.com/science/article/abs/pii/S1877959X1500028X?via%3Dihub - Sato K, Takano A, Konnai S, Nakao M, Ito T, Koyama K, et al. Human infections with Borrelia miyamotoi, Japan. Emerg Infect Dis. (2014) 20:1391–3. doi: 10.3201/eid2008.131761
https://wwwnc.cdc.gov/eid/article/20/8/13-1761_article - Gugliotta JL, Goethert HK, Berardi VP, Telford SR. Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient. N Engl J Med. (2013) 368:240–5. doi: 10.1056/NEJMoa1209039
https://www.nejm.org/doi/10.1056/NEJMoa1209039 - Platonov AE, Karan LS, Kolyasnikova NM, Makhneva NA, Toporkova M, Maleev VV, et al. Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia.mEmerg Infect Dis. (2011) 17:1816–23. doi: 10.3201/eid1710.101474
https://wwwnc.cdc.gov/eid/article/17/10/10-1474_article - Barbour AG, Bunikis J, Travinsky B, Hoen AG, Diuk-Wasser MA, Fish D, et al. Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species. Am J Trop Med Hyg. (2009) 81:1120–31. doi: 10.4269/ajtmh.2009.09-0208
http://www.ajtmh.org/content/journals/10.4269/ajtmh.2009.09-0208
DISULFIRAM
- Liegner KB. Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases. Antibiotics (Basel). 2019 May 30;8(2). pii: E72. doi: 10.3390/antibiotics8020072
https://pubmed.ncbi.nlm.nih.gov/31151194/ - Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease
https://clinicaltrials.gov/ct2/show/NCT03891667 - Pothineni VR, Wagh D, Babar MM, et al. Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening.Drug Des Devel Ther. 2016;10:1307-22
https://pubmed.ncbi.nlm.nih.gov/27103785/ - Hari-Hara SK Potula, Jahanbanoo Shahryari, Mohammed Inayathullah, Andrey Victorovich Malkovskiy, Kwang-Min Kim, Jayakumar Rajadas. Repurposing disulfiram (Tetraethylthiuram Disulfide) as a potential drug candidate against Borrelia burgdorferi in vitro and in vivo
https://www.biorxiv.org/content/10.1101/842286v1.full - Scheibel LW, Adler A, Trager W. Tetraethylthiuram disulfide (Antabuse) inhibits the human malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A. 1979;76(10):5303-7
https://pubmed.ncbi.nlm.nih.gov/388434/ - Gao, J.; Gong, Z.; Montesano, D.; Glazer, E.; Liegner, K. “Repurposing” Disulfiram in the Treatment of Lyme Disease and Babesiosis: Retrospective Review of First 3 Years’ Experience in One Medical Practice. Antibiotics 2020, 9, 868.
https://www.mdpi.com/2079-6382/9/12/868?type=check_update&version=1#cite
GRAVIDANZA
- https://www.thechronicleherald.ca/news/local/lyme-disease-can-cause-pregnancy-complications-study-292577/
- IL CDC (Centers for Disease Control and Prevention) ha recentemente pubbicato sul proprio sito degli aggiornamenti riguardanti i rischi legati alla trasmissione materno fetale della Malattia di Lyme
https://www.scientificarchives.com/admin/assets/articles/pdf/healthy-fetal-outcomes-using-a-novel-treatment-for-maternal-lyme-disease-and-babesiosis-during-consecutive-pregnancies-a-case-study-and-literature-review-20200205050242.pdf?fbclid=IwAR2vWtKYiNvscTH9rKDOIntPLy2CFopfFPJMBCkk1jU2O0gfgH7UAwqijN4 - Lisa A. Waddell. A systemic review on the impact of gestational Lyme disease in humans on the fetus and newborn. 2018 Nov 12; 13(11): e0207067 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231644/
- Mylonas I (2011) Borreliosis During Pregnancy: A Risk for the Unborn Child? Vector Borne Zoonotic Dis. 11:891-8.
https://pubmed.ncbi.nlm.nih.gov/20925520/ - Lakos A, Solymosi N (2010) Maternal Lyme borreliosis and pregnancy outcome. Int J Infect Dis 14(6), e494-8.
https://pubmed.ncbi.nlm.nih.gov/19926325/ - Walsh CA, Mayer EW, Baxi LV. (2007). Lyme disease in pregnancy: case report and review of the literature. Obstet Gynecol Surv. 2007 Jan;62(1):41-50. https://pubmed.ncbi.nlm.nih.gov/17176487/
- Jones CR, Smith H, Gibb E, Johnson L (2005) Gestational Lyme Disease: Case Studies of 102 Live Births. Lyme Times. Gestational Lyme Studies 34-36
https://www.lymedisease.org/wp-content/uploads/2014/08/Image21-Gestational-Lyme-Studies.pdf - Brzostek T. (2004). “[Human granulocytic ehrlichiosis co-incident with Lyme borreliosis in pregnant woman—a case study].”Przegl Epidemiol58(2): 289-94
https://www.prohealth.com/library/human-granulocytic-ehrlichiosis-co-incident-with-lyme-borreliosis-in-pregnant-woman-a-case-study-13009 - Trevisan G, Stinco G, Cinco M. Neonatal skin lesions due to a spirochetal infection: a case of congenital Lyme borreliosis? Int J Dermatol. 1997;36(9):677-80. https://www.ncbi.nlm.nih.gov/pubmed/9352409
- Schmidt. B. L., Aberer E, et al. (1995).
“Detection of Borrelia burgdorferi DNA by polymerase chain reaction in the urine and breast milk of patients with Lyme borreliosis
https://pubmed.ncbi.nlm.nih.gov/7648832/ - Gardner T. (2000) Lyme disease. 66 Pregnancies complicates by Lyme Borreliosis. lnfec Dis Fetus and Newborn Infant. Saunders
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207067 - Gardner, T. (1995). Lyme disease. Infectious diseases of the fetus and newborn infant. J. S. Remington and J. O. Klein. Philadelphia, Saunders. Chap. 11: 447-528.
https://www.lebpedsoc.org/doc/HIGHLIGHTS%20FROM%20THE%20LITERATURE/Infectious%20Diseases%20of%20the%20Fetus%20and%20Newborn_%20Expert%20Consult%20.pdf - Strobino, B. A., C. L. Williams, S. Abid, R. Chalson, and P. Spierling. 1993. Lyme disease and pregnancy outcome: a prospective study of two thousand prenatal patients. Am. J. Obstet. Gynecol. 169:367–374.
https://www.ncbi.nlm.nih.gov/pubmed/8362948 - Bale, J. F., Jr. and J. R. Murph (1992). “Congenital infections and the nervous system.” Pediatr Clin North Am 39(4): 669-90.
https://www.ncbi.nlm.nih.gov/pubmed/1321971 - Carlomagno G; Luksa V; Candussi G; Rizzi GM; Trevisan G Acta Eur Fertil 1988 Sep-Oct;19(5):279-81 Dept. of Obstetrics and Gynecology, University of Trieste School of Medicine. Lyme Borrelia positive serology associated with spontaneous abortion in an endemic Italian area
https://pubmed.ncbi.nlm.nih.gov/3252658/ - MacDonald, A. B., J. L. Benach, et al. (1987). “Stillbirth following maternal Lyme disease.
” N Y State J Med 87(11): 615-6. - MacDonald, A. B. (1986). “Human fetal borreliosis, toxemia of pregnancy, and fetal death.”
Zentralbl Bakteriol Mikrobiol Hyg [A] 263(1-2): 189-200. - MacDonald, A. B. (1989). “Gestational Lyme borreliosis. Implications for the fetus.”
Rheum Dis Clin North Am 15(4):657-77 - Markowitz, L. E., A. C. Steere, et al. (1986). “Lyme disease during pregnancy.”
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PERSISTENZA POST-TRATTAMENTO
- Rebman AW, Aucott JN. Post-treatment Lyme Disease as a Model for Persistent Symptoms in Lyme Disease. Front Med (Lausanne). 2020;7:57. https://pubmed.ncbi.nlm.nih.gov/32161761/
- Sapi E, Kasliwala RS, Ismail H, Torres JP, Oldakowski M, Markland S, Gaur G, Melillo A, Eisendle K, Liegner KB, Libien J, Goldman JE. The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme Disease. Antibiotics (Basel). 2019;8(4)
https://www.ncbi.nlm.nih.gov/pubmed/31614557 - Feng J, Li T, Yee R, Yuan Y, Bai C, Cai M, Shi W, Embers M, Brayton C, Saeki H, Gabrielson K, Zhang Y. Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure. Discov Med. 2019;27(148):125-38
https://www.ncbi.nlm.nih.gov/pubmed/30946803 - Hodzic E, Imai DM, Escobar E. Generality of Post-Antimicrobial Treatment Persistence of Borrelia burgdorferi Strains N40 and B31 in Genetically Susceptible and Resistant Mouse Strains. Infect Immun. 2019;87(10)
https://www.ncbi.nlm.nih.gov/pubmed/31308087 - Lacout A, El Hajjam M, Marcy PY, Perronne C. The Persistent Lyme Disease: "True Chronic Lyme Disease" rather than "Post-treatment Lyme Disease Syndrome". J Glob Infect Dis. 2018;10(3):170-1
http://www.jgid.org/article.asp?issn=0974-777X;year%3D2018;volume%3D10;issue%3D3;spage%3D170;epage%3D171;aulast%3DLacout - Maccallini P, Bonin S, Trevisan G. Autoimmunity against a glycolytic enzyme as a possible cause for persistent symptoms in Lyme disease. Med Hypotheses. 2018;110:1-8.
https://www.ncbi.nlm.nih.gov/pubmed/29317049 - Jennifer M Coughlin, Ting Yang, Alison W Rebman, Kathleen T Bechtold, Yong Du, William B Mathews, Wojciech G Lesniak, Erica A Mihm, Sarah M Frey, Erica S Marshall, Hailey B Rosenthal, Tristan A Reekie, Michael Kassiou, Robert F Dannals, Mark J Soloski, John N Aucott, Martin G Pomper Imaging Glial Activation in Patients With Post-Treatment Lyme Disease Symptoms: A Pilot Study Using [11C]DPA-713 PET 2018 Dec 19;15(1):346.
https://pubmed.ncbi.nlm.nih.gov/30567544/ - Marianne J. Middelveen, Jennie M Burke, Eva Sapi, Katherine R. Filush. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease (2018) https://www.researchgate.net/publication/324539470_Persistent_Borrelia_Infection_in_Patients_with_Ongoing_Symptoms_of_Lyme_Disease
- Rebman AW, Bechtold K, Yang T, Mihm EA, Soloski MJ, Novak CB, et al. The clinical, symptom, and quality-of-life characterization of a well-defined group of patients with posttreatment Lyme disease syndrome. Front Med. (2017) 4:224. doi: 10.3389/fmed.2017.00224
https://pubmed.ncbi.nlm.nih.gov/29312942/ - Embers ME, Hasenkampf NR, et al. (2017) Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189071 - Hodzic E, Barthold SW (2014) Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice. PLoS ONE 9(1): e86907.
https://www.ncbi.nlm.nih.gov/pubmed/24466286 - Marques, A. et al. Xenodiagnosis to Detect Borrelia burgdorferi Infection: A First-in-Human Study. Clinical Infectious Diseases DOI: 10.1093/cid/cit939 (2014).
https://www.ncbi.nlm.nih.gov/pubmed/24523212 - Embers, M. et al. Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic treatment of Disseminated Infection. 2012 PLoS ONE 7(1): e29914. doi:10.1371/journal.pone
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029914 - Fallon BA, Petkova E, Keilp J, Britton C. A reappraisal of the U.S. clinical trials of Post-Treatment Lyme Disease Syndrome. Open Neurology Journal. 2012;6(Supp. 1-M2):79-87.
https://www.ncbi.nlm.nih.gov/pubmed/23091568 - Delong et al. Antibiotic retreatment of Lyme disease in patients with persistent symptoms: A biostatistical review of randomized, placebo controlled, clinical trials. Contemporary Clinical Trials 33 (2012), 1132-1142
https://www.ncbi.nlm.nih.gov/pubmed/22922244 - Skogman et al. Long-term clinical outcome after Lyme neuroborreliosis in childhood. Pediatrics. 2012; 130: 262-9
. https://pubmed.ncbi.nlm.nih.gov/22802606/ - Delong AK, Blossom B, Maloney EL, Phillips SE. Antibiotic retreatment of Lyme disease in patients with persistent symptoms: a biostatistical review of randomized, placebo-controlled, clinical trials. Contemp Clin Trials. 2012;33(6):1132-42
https://www.ncbi.nlm.nih.gov/pubmed/22922244 - European Neuroborreliosis: Quality of Life 30 Months After Treatment Acta Neurol Scand 2011 Nov;124(5):349-54
https://pubmed.ncbi.nlm.nih.gov/21303350/ - Fallon BA, Keilp JG, Corbera KM, Petkova E, Britton CB, Dwyer E, et al. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology. 2008 Mar 25:992-1003
https://www.ncbi.nlm.nih.gov/pubmed/17928580 - Cairns & Godwin. Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms. Int J Epidemiol. 2005; 34: 1340-5
.https://pubmed.ncbi.nlm.nih.gov/16040645/ - Krupp LB, Hyman LG, Grimson R, Coyle PK, Melville P, Ahnn S, et al. Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology. 2003 Jun 24;60(12):1923-30
https://www.ncbi.nlm.nih.gov/pubmed/12821734 - Berglund J, Stjernberg L, Ornstein K, Tykesson-Joelsson K, Walter H. 5-y Follow-up study of patients with neuroborreliosis. Scand J Infec Dis. 2002;34(6):421-5.
https://www.ncbi.nlm.nih.gov/pubmed/12160168 - Klempner M, Hu L, Evans J, Schmid C, Johnson G, Trevino R, et al. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. The New Eng-land journal of medicine. 2001 Jul 12:85-92
https://www.ncbi.nlm.nih.gov/pubmed/11450676 - Fallon BA, et al. Repeated antibiotic treatment in chronic Lyme disease, Journal of Spirochetal and Tick-borne Diseases, 1999; 6 (Fall/Winter):94-101
https://www.ilads.org/wp-content/uploads/2018/10/JSTBD-VOL6-FALL-WINTER-99-3.pdf - Donta, ST, Tetracycline therapy in chronic Lyme disease. Chronic Infectious Diseases, 1997; 25 (Suppl 1): 552-56
https://www.ncbi.nlm.nih.gov/pubmed/9233665 - Straubinger RK, et al. Persistence of Borrelia burgdorferi in Experimentally Infected Dogs after Antibiotic Treatment. J Clin Microbiol 1997;35(1):111-116
https://www.ncbi.nlm.nih.gov/pubmed/8968890 - Valesová H, Mailer J, Havlík J, Hulínská D, Hercogová J. Long-term results in patients with Lyme arthritis following treatment with ceftriaxone. Infection. 1996 Jan-Feb;24(1):98-102
https://www.ncbi.nlm.nih.gov/pubmed/8852482 - Bayer ME, Zhang L, Bayer MH. Borrelia burgdorferi DNA in the urine of treated patients with chronic Lyme Disease symptoms. A PCR study of 97 cases. Infection 1996. Sept-Oct;24(5):347-53
https://www.ncbi.nlm.nih.gov/pubmed/8923044 - Girschick HJ, et al. Intracellular persistence of Borrelia burgdorferi in human synovial cells. Rheumatol Int 1996;16(3):125-132
https://www.ncbi.nlm.nih.gov/pubmed/8893378 - Karma A, et al. Long term follow-up of chronic Lyme neuroretinitis. Retina 1996;16:505-509
https://www.ncbi.nlm.nih.gov/pubmed/9002133 N A - Shadick, C B Phillips, E L Logigian, A C Steere, R F Kaplan, V P Berardi, P H Duray, M G Larson, E A Wright, K S Ginsburg, J N Katz, M H Liang 1994 Oct 15;121(8):560-7. The Long-Term Clinical Outcomes of Lyme Disease. A Population-Based Retrospective Cohort Study
https://pubmed.ncbi.nlm.nih.gov/8085687/ - Bradley JF,et al, The Persistence of Spirochetal Nucleic Acids in Active Lyme Arthritis. Ann Int Med 1994;487-9
https://www.ncbi.nlm.nih.gov/pubmed/8093136 - Masters EJ, et al. Spirochetemia after continuous high-dose oral amoxicillin therapy. Infect Dis Clin Practice 1994;3:207-208 E S Asch1, D I Bujak, M Weiss, M G Peterson, A Weinstein 1994 Mar;21(3):454-61. Lyme Disease: An Infectious and Postinfectious Syndrome
https://www.ncbi.nlm.nih.gov/pubmed/8006888 - Haupl T, et al. Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis. Arthritis Rheum 1993;36:1621-1626
https://www.ncbi.nlm.nih.gov/pubmed/8240439 - Fitzpatrick JE, et al. Chronic septic arthritis caused by Borrelia burgdorferi. Clin Ortho 1993 Dec;(297):238-41
https://www.ncbi.nlm.nih.gov/pubmed/8242938 - Fraser DD, et al. Molecular detection of persistent Borrelia burgdorferi in a man with dermatomyositis. Clinical and Exper Rheum. 1992;10:387-390 https://www.ncbi.nlm.nih.gov/pubmed/1395222
- Keller TL, et al. PCR detection of Borrelia burgdorferi DNA in cerebrospinal fluid of Lyme neuroborreliosis patients. Neurology 1992;43:32-42 https://www.ncbi.nlm.nih.gov/pubmed/1734321
- Ma Y, et al. Intracellular localization of Borrelia burgdorferi within human endothelial cells. Infect Immun 1991;59:671-678
https://www.ncbi.nlm.nih.gov/pubmed/1987083 - H W Pfister1, V Preac-Mursic, B Wilske, E Schielke, F Sörgel, K M Einhäupl. Randomized Comparison of Ceftriaxone and Cefotaxime in Lyme Neuroborreliosis 1991 Feb;163(2):311-8.
https://www.ncbi.nlm.nih.gov/pubmed/1988514 - Preac-Mursic V, et al. Persistence of Borrelia burdorferi and Histopathological Alterations in Experimentally Infected Animals. A comparison with Histopathological Findings in Human Lyme Dis-ease. Infection 1990;18(6):332-341
https://link.springer.com/article/10.1007/BF01646399 - E L Logigian1, R F Kaplan, A C Steere Chronic Neurologic Manifestations of Lyme Disease 1990 Nov 22;323(21):1438-44
https://pubmed.ncbi.nlm.nih.gov/2172819/ - Preac-Mursic V, et al. Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis. Infection 1989;17:355-359.
https://www.ncbi.nlm.nih.gov/pubmed/2613324 - Diringer MN, et al, Lyme meningoencephalitis- report of a severe, penicillin resistant case. Arthritis & Rheum, 1987;30:705-708
https://www.ncbi.nlm.nih.gov/pubmed/3649235 - Treatment Delays Increase Risk of Persistent Illness in Lyme Disease, December 15, 2020 By Johns Hopkins Lyme Disease Research Center Hirsch AG, Poulsen MN, Nordberg C, Moon KA, Rebman AW, Aucott JN, Heaney CD and Schwartz BS (2020)
Risk Factors and Outcomes of Treatment Delays in Lyme Disease: A Population-Based Retrospective Cohort Study.
Front. Med. 7:560018. doi: 10.3389/fmed.2020.560018 - Horowitz, R & Freeman, Phyllis. (2018, Nov 5). Precision Medicine: The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2. Retrieved from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316761/ - Horowitz, R.I., Murali, K., Gaur, G. et al. Effect of dapsone alone and in combination with intracellular antibiotics against the bio-film form of B. burgdorferi. BMC Res Notes 13, 455 (2020)
https://doi.org/10.1186/s13104-020-05298-6 - The Platelet Fraction is a Novel Reservoir to Detect Lyme Borrelia in Blood Victoria P. Sanderson, Iain L. Mainprize, Lisette Verzijlenberg, Cezar M. Khursigara and Melanie K. B. Wills 2020 Oct 29;9(11):366.
https://www.mdpi.com/2079-7737/9/11/366 - Richard I. Horowitz hHHS Babesia and Tick-borne Pathogens Subcommittee and Phyllis R. Freeman Efficacy of Double-Dose Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases and Retrospective Chart Review Published: 22 October 2020 https://www.mdpi.com/2079-6382/9/11/725
- Allen C Steere Sheryn M Angelis Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis October 2006 Arthritis & Rheumatology 54(10):3079-86
https://pubmed.ncbi.nlm.nih.gov/17009226/ - Anam Hareem, Iman Dabiri, Nida Zaheer, Ahmet Z Burakgazi Medically Refractory Neuroborreliosis Case Presented with Coexistance Involvements of Cranial 7 and 8 Nerves Neurol Int 2021 Mar 18;13(1):125-129. doi: 10.3390/neurolint13010012.
https://pubmed.ncbi.nlm.nih.gov/33803548/
DIAGNOSTICA
- Alexis Lacout, Pierre Yves Marcy, Marie Mas, Christian Perronne, Michel Franck. Value of Patient Population Selection and Lyme Borreliosis Tests J Clin Microbiol. 2019 Feb 27;57(3):e01517-18.
https://pubmed.ncbi.nlm.nih.gov/30814303/ - Lacout A, Mone Y, Franck M, Marcy PY, Mas M, Veas F, Perronne C. Blood cell disruption to significantly improve the Borrelia PCR detection sensitivity in borreliosis in humans. Med Hypotheses. 2018;116:1-3.
https://pubmed.ncbi.nlm.nih.gov/29857888/ - Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding. Embers, M. et al. PLoS ONE 2017 Dec13; 12(12): e0189071)
https://www.ncbi.nlm.nih.gov/pubmed/29236732 - Jahfari S, Sarksyan DS, Kolyasnikova NM, Hovius JW, Sprong H, Platonov AE. Evaluation of a serological test for the diagnosis of Borrelia miyamotoi disease in Europe. Journal of microbiological methods. 2017;136:11-6.
https://pubmed.ncbi.nlm.nih.gov/28259789/ - Bonin S. Diagnostic tools for borrelia assessment in humans. Open Dermatology Journal. 2016;10(Suppl 1: M7):62-9.
https://benthamopen.com/ABSTRACT/TODJ-10-62 - Monica E Embers, Nicole R Hasenkampf , Mary B Barnes, Elizabeth S Didier, Mario T Philipp, Amanda C Tardo Five-Antigen Fluorescent Bead-Based Assay for Diagnosis of Lyme Disease 2016 Apr 4;23(4):294-303.
https://pubmed.ncbi.nlm.nih.gov/26843487/ - Ashutosh Verma, Catherine A. Brissette, Amy Bowman, and Brian Stevenson. Borrelia burgdorferi BmpA Is a Laminin-Binding Protein▿ Infect Immun. 2009 Nov; 77(11): 4940–4946.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772523/ - Dejmkova H, Hulinska D, Tegzova D, Pavelka K, Gatterova J, Vavrik P. Seronegative Lyme arthritis caused by Borrelia garinii. Clin Rheumatol. 2002 Aug;21(4):330-4
https://www.ncbi.nlm.nih.gov/pubmed/12189466 - Brunner M. New method for detection of Borrelia burgdorferi antigen complexed to antibody in seronegative Lyme disease. J Immunol Methods. 2001 Mar 1;249(1-2):185-90.
https://www.ncbi.nlm.nih.gov/pubmed/11226475 - Breier F, Khanakah G, Stanek G, Kunz G, Aberer E, Schmidt B, Tappeiner G. Isolation and polymerase chain reaction typing of Borrelia afzelii from a skin lesion in a seronegative patient with generalized ulcerating bullous lichen sclerosus et atrophicus. Br J Dermatol. 2001 Feb;144(2):387-92.
https://www.ncbi.nlm.nih.gov/pubmed/11251580 - Kaiser R. False-negative serology in patients with neuroborreliosis and the value of employing of different borrelial strains in serological assays. J Med Microbiol. 2000
https://www.ncbi.nlm.nih.gov/pubmed/11023188 - Brown SL, Hansen SL, Langone JJ. (FDA Medical Bulletin) Role of serology in the diagnosis of Lyme disease. JAMA. 1999 Jul 7;282(1):62-6. https://www.ncbi.nlm.nih.gov/pubmed/10404913
- Steere AC. Seronegative Lyme disease. JAMA. 1993 Sep 15;270(11):1369
https://jamanetwork.com/journals/jama/article-abstract/408467 - Serodiagnosis of Lyme Borreliosis by Western Immunoblot: Reactivity of Various Significant Antibodies against Borrelia burgdorferi. Journal of Clinical Microbiology, Feb. 1992, p. 370-376
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC265062/ - “The significance of various antibodies against Borrelia burgdorferi was studied by Western blot (immunoblot) by using 578 human serum samples. The proteins regularly detected by using samples from patients with Lyme borreliosis were those with bands with molecular masses of 94, 83, 75, 66, 60, 55, 46, 41, 39, 34, 31, 29, 22, and 17 kDa. The detectable frequencies of most of these proteins appeared to be significantly different between the sera from patients with Lyme borreliosis and those from normal control individuals as well as from the group with syphilis” Schutzer SE, Coyle PK, Belman AL, Golightly MG, Drulle J. Sequestration of antibody to Borrelia burgdorferi in immune complexes in seronegative Lyme disease. Lancet. 1990 Feb 10;335(8685):312-5
https://www.ncbi.nlm.nih.gov/pubmed/1967770 - Pikelj F, Strle F, Mozina M. Seronegative Lyme disease and transitory atrioventricular block. Ann Intern Med 1989 Jul 1;111(1):90. Oct;49(10):911-5. https://www.ncbi.nlm.nih.gov/pubmed/2735630
- Dattwyler RJ, Volkman DJ, Luft BJ, Halperin JJ, Thomas J, Golightly MG. Seronegative Lyme disease. Dissociation of specific T- and B-lymphocyte responses to Borrelia burgdorferi. N Engl J Med. 1988 Dec 1;319(22):1441-6
https://www.ncbi.nlm.nih.gov/pubmed/3054554 - Ruben Magni, Raghad Almofee, Alessandra Luchini. Evaluation of pathogen specific urinary peptides in tick-borne illnesses. Scientific Reports volume 10, Article number: 19340 (2020).
https://www.nature.com/articles/s41598-020-75051-3 - Blake W. Buchan,corresponding authora Dean A. Jobe,b Michael Mashock,a Derek Gerstbrein,a Matthew L. Faron,a Nathan A. Ledeboer,a and Steven M. Callisterb. Evaluation of a Novel Multiplex High-Definition PCR Assay for Detection of Tick-Borne Pathogens in Whole-Blood Specimens. J Clin Microbiol. 2019 Nov; 57(11): e00513-19. Published online 2019 Oct 23. Prepublished online 2019 Sep 4. doi: 10.1128/JCM.00513-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812998/ - Jinyu Shan1*†, Ying Jia1†, Louis Teulières2, Faizal Patel1 and Martha R. J. Clokie1 Targeting Multicopy Prophage Genes for the Increased Detection of Borrelia burgdorferi Sensu Lato (s.l.), the Causative Agents of Lyme Disease, in Blood. Front. Microbiol., 15 March 2021 |
https://doi.org/10.3389/fmicb.2021.651217
https://www.frontiersin.org/articles/10.3389/fmicb.2021.651217/full
TRATTAMENTI PROLUNGATI
- Oksi, J., et al. Borrelia burgdorferi detected by culture and PCR in clinical relapse of disseminated Lyme borreliosis. Ann Med, 1999. 31(3):p.225-32→32/165 This last study detected chronic persistent Lyme by both PCR and culture.
- Oksi, J et al., Comparison of oral cefixime and intravenous ceftriaxone followed by oral amoxicillin in disseminated Lyme borreliosis. Eur J Clin Microbiol Infect Dis, 1998. 17(10)p715-9→ 30 pts w/ chronic Lyme disease were treated for 100 days, and 90% had good or excellent responses
https://www.ncbi.nlm.nih.gov/pubmed/9865985 - Donta, ST., Tetracycline therapy for chronic Lyme disease. Clin Infect Dis, 1997. 25 Suppl 1: p.S52-6. →277 pts with chronic LD treated between 1-11 months: 20% cured, 70% improved, 10% failed
- Wahlberg,P. et al, Treatment of late Lyme borreliosis. J Infect, 1994. 29(3): p255-61 →31% improved w/ 14 days of Rocephin, 89% improved w/ Rocephin + 100d of Amoxicillin and Probenecid, 83% improved w/ Rocephin, then 100 days of cephadroxil
ALTRI STUDI RECENTI
- Venkata Raveendra Pothineni, Hari-Hara Sk Potula, Aditya Ambati, Venkata Vamsee Aditya Mallajosyula, Brindha Sridharan, Mohammed Inayathullah, Mohamed Sohail Ahmed, Jayakumar Rajadas Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31
https://www.nature.com/articles/s41598-020-59600-4 - Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O. Clinical spectrum of Lyme disease. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2019;38(2):201-8. https://www.ncbi.nlm.nih.gov/pubmed/30456435
- Host metabolic response in early Lyme Disease . Proteome Res.2020, 19, 2, 610-623
https://pubs.acs.org/doi/10.1021/acs.jproteome.9b00470?goto=supporting- info&fbclid=IwAR1YGNbBJVDMg_O09QIvxrcFUAruk6o-_9NRPftUIPduJq-ynKzJQgrhgaA - I ricercatori dell' Università del Meriland stanno collaborando con il DOD per studiare come le infezioni da zecca si muovano dentro e fuori i vasi sanguigni fornendo una panoramica sui meccanismi di risposta del sistema immunitario nei primati.
http://outbreaknewstoday.com/university-of-maryland-and-dod-collaborate-to-study-tick-borne-infections-using-3-d-models-of-human-blood-vessels-96986/?fbclid=IwAR2HjZxEGm8iAQdtdK-6lJ8thf0z_i14WbowxE4ayE_HeifDZafovm8bWa8 - Mancini F, Vescio MF, Toma L, Di Luca M, Severini F, Caccio SM, Mariano C, Nicolai G, Laghezza Masci V, Fausto AM, Pezzotti P, Ciervo A. Detection of tick-borne pathogens in ticks collected in the suburban area of Monte Romano, Lazio Region, Central Italy. Ann Ist Super Sanita. 2019;55(2):143-50
https://www.ncbi.nlm.nih.gov/pubmed/31264637 - Rimoldi SG, Merli S, Bestetti G, Giacomet V, Cislaghi G, Grande R, Sanzani S, Pagani C, Trevisan G, E DEF, Gismondo MR, Ruzic-Sabljic E, Exodes study g. Occurrence of Lyme disease infection in a non endemic area in Northern Italy. G Ital Dermatol Venereol. 2018. https://www.ncbi.nlm.nih.gov/pubmed/29600690
- Alexis Lacout, Juliette Thariat, Mostafa El Hajjam, Pierre Yves Marcy & Christian Perronne Lyme disease & co-infections: role of adaptive immune system FUTURE MICROBIOLOGYVOL. 13, NO. 6
https://www.futuremedicine.com/doi/abs/10.2217/fmb-2017-0252 - Jie Feng , Wanliang Shi, Judith Miklossy, Genevieve M Tauxe, Conor J McMeniman , Ying Zhang Identification of Essential Oils With Strong Activity Against Stationary Phase Borrelia burgdorferi 2018 Oct 16;7(4):89.
https://pubmed.ncbi.nlm.nih.gov/30332754/ - Lisa K. Blum, Julia Z. Adamska, Dale S. Martin, Alison W. Rebman, Serra E. Elliott, Richard R. L. Cao, Monica E. Embers, John N. Aucott, Mark J. Soloski, and William H. Robinson Robust B Cell Responses Predict Rapid Resolution of Lyme Disease Front Immunol. 2018; 9: 1634. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060717/
- Di Meo N, Retrosi C, Corneli P, Trevisan G. Multiple erythema migrans due to borreliosis. G Ital Dermatol Venereol. 2019;154(5):599-600.
https://www.minervamedica.it/en/journals/dermatologia-venereologia/article.php?cod=R23Y2019N05A0599 - Bonin S, Stinco G, Patriarca MM, Trevisini S, di Meo N, Trevisan G. Could co-infection with Anaplasma play a role in Borrelia-associated primary cutaneous marginal zone B-cell lymphomas? Indian J Dermatol Ve. 2016;82(1):81-4
https://www.ncbi.nlm.nih.gov/pubmed/26728821 - Marques AR. Lyme Neuroborreliosis. Continuum (Minneap Minn). 2015;21(6 Neuroinfectious Disease):1729-44 https://www.ncbi.nlm.nih.gov/pubmed/26633786
- Anuj Sharma, Sandesh Guleria, Reena Sharma, and Anita Sharma Lyme Disease: A Case Report with Typical and Atypical Lesions Indian Dermatol Online J. 2017 Mar-Apr; 8(2): 124–127.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372433/ - Dumic I, Vitorovic D, Spritzer S, Sviggum E, Patel J, Ramanan P. Acute transverse myelitis - A rare clinical manifestation of Lyme neuroborreliosis. IDCases. 2019;15:e00479
https://www.ncbi.nlm.nih.gov/pubmed/30622896 - Keilp JG, Corbera K, Gorlyn M, Oquendo MA, Mann JJ, Fallon BA. Neurocognition in Post-Treatment Lyme Disease and Major Depressive Disorder. Arch Clin Neuropsychol. 2019
https://www.ncbi.nlm.nih.gov/pubmed/30418507 - Sanchez-Vicente S, Tagliafierro T, Coleman JL, Benach JL, Tokarz R. Polymicrobial Nature of Tick- Borne Diseases. MBio. 2019;10(5) https://mbio.asm.org/content/10/5/e02055-19
- Pauluzzi P, Bonin S, Gonzalez Inchaurraga MA, Stanta G, Trevisan G. Detection of spirochaetal DNA simultaneously in skin biopsies, peripheral blood and urine from patients with erythema migrans. Acta dermato-venereologica. 2004;84(2):106-10. https://www.researchgate.net/publication/8500822_Detection_of_Spirochaetal_DNA_Simultaneously_ in_Skin_Biopsies_Peripheral_Blood_and_Urine_from_Patients_with_Erythema_Migrans
- In this review, the authors provide an overview on the ability of Borrelia burgdorferi to infect a host and the factors which decisively affect the nature or outcome of this infection that have been demonstrated in vivo, primarily in mouse models.
Jenifer Coburn, Brandon Garcia, Linden T. Hu, Mollie W. Jewett, Peter Kraiczy, Steven J. Norris and Jon Skare Curr. Lyme Disease Pathogenesis Issues Mol. Biol. (2022) 42: 473-518.
https://doi.org/10.21775/cimb.042.473
per leggere il testo integrale
https://www.caister.com/cimb/v/v42/473.pdf - Gutierrez-Hoffmann MG, O’Meally RN, Cole RN, Tiniakou E, Darrah E and Soloski MJ (2020) Borrelia burgdorferi-Induced Changes in the Class II Self-Immunopeptidome Displayed on HLA-DR Molecules Expressed by Dendritic Cells. Front. Med. 7:568. doi: 10.3389/fmed.2020.00568
https://www.hopkinslyme.org/research/lyme-disease-bacteria-induce-changes-in-self-immunopeptides-expressed-by-dendritic-cells/ - Giusto Trevisan Serena Bonin and Maurizio Ruscio A Practical Approach to the Diagnosis of Lyme Borreliosis: From Clinical Heterogeneity to Laboratory Methods Front. Med., 23 July 2020
https://www.frontiersin.org/articles/10.3389/fmed.2020.00265/full?fbclid=IwAR26KuY-vOJowUnMezUU1XtjwJuL4gZ-2M4jvd05vW85qEvzdWfp6U83224 - Elizabeth L. Maloney, MD, 2009 The Need for Clinical Judgment in the Diagnosis and Treatment of Lyme Disease
https://www.jpands.org/vol14no3/maloney.pdf - Edward B Breitschwerdt , Julie M Bradley , Ricardo G Maggi , Erin Lashnits , Paul Reicherter Bartonella Associated Cutaneous Lesions (BACL) in People with Neuropsychiatric Symptoms Pathogens 2020 Dec 4;9(12):1023. doi: 10.3390/pathogens9121023.
https://pubmed.ncbi.nlm.nih.gov/33291688/ - Timothy Casselli ,Ali Divan,Emilie E. Vomhof-DeKrey,Yvonne Tourand,Heidi L. Pecoraro,Catherine A. Brissette. A murine model of Lyme disease demonstrates that Borrelia burgdorferi colonizes the dura mater and induces inflammation in the central nervous system Published: February 1, 2021
https://doi.org/10.1371/journal.ppat.1009256
PEDIATRIA
- NEUROLOGICAL MANIFESTATIONS OF LYME DISEASE IN CHILDREN Dorothy M. Pietrucha, M.D., P.A.
https://sites.google.com/site/drjoneskids/symptoms-literature/neuro-manifestations - KIDS AND LYME DISEASE HOW IT AFFECTS THEIR LEARNING Sandy Berenbaum, LCSW, BCD
https://www.lymedisease.org/wp-content/uploads/2014/08/Image19-Berenbaum-Kids-Lyme-and-Effects-on-Learning.pdf - What Doctors Need To Know About Tick Borne Diseases in the Pediatric Patient, April 20, 2013 Ann F Corson MD
https://www.lymedisease.org/wp-content/uploads/2014/08/Image16-Corson-Pediatric.pdf - D J Elliott , S C Eppes, J D Klein Teratogen update: Lyme disease Teratology 2001 Nov;64(5):276-81. doi: 10.1002/tera.1074.
https://pubmed.ncbi.nlm.nih.gov/11745834/
COINFEZIONI
- Yi Yang, Jevan Christie,Liza Köster 3OrcID,Aifang Du, andChaoqun Yao, OrcID Emerging Human Babesiosis with “Ground Zero” in North America. Microorganisms 2021, 9(2), 440;
https://doi.org/10.3390/microorganisms9020440
https://www.mdpi.com/2076-2607/9/2/440/htm# - Erin Lashnits, Ricardo Maggi, Fredrik Jarskog, Julie Bradley, Edward Breitschwerdt, Flavio Frohlich. Schizophrenia and Bartonella spp. Infection: A Pilot Case-Control Study. Vector Borne Zoonotic Dis 2021 Mar 15. doi: 10.1089/vbz.2020.2729.
https://pubmed.ncbi.nlm.nih.gov/33728987/
LYME DISTURBI NEUROPSICHIATRICI
- Robert C Bransfield, Dylan M Aidlen , Michael J Cook , Sagar Javia. A Clinical Diagnostic System for Late-Stage Neuropsychiatric Lyme Borreliosis Based upon an Analysis of 100 Patients. Healthcare (Basel). 2020 Jan 6;8(1):13. doi: 10.3390/healthcare8010013.
https://pubmed.ncbi.nlm.nih.gov/31935905/ - Hans Christiaan KleinLot de WitteRobert BransfieldPeter Paul De Deyn. PET Imaging of Microglia Activation and Infection in Neuropsychiatric Disorders with Potential Infectious Origin. PET and SPECT in Neurology pp 873-892
https://www.researchgate.net/publication/346327244_PET_Imaging_of_Microglia_Activation_and_Infection_in_Neuropsychiatric_Disorders_with_Potential_Infectious_Origin - Erin Lashnits, Ricardo Maggi, Fredrik Jarskog, Julie Bradley, Edward Breitschwerdt, and Flavio Frohlich. Schizophrenia and Bartonella spp. Infection: A Pilot Case–Control Study 15 Mar 2021
https://doi.org/10.1089/vbz.2020.2729
https://www.liebertpub.com/doi/abs/10.1089/vbz.2020.2729
LYME e la VISTA
- Patterson-Fortin J, Kohli A, Suarez MJ, Miller PE. Ocular Lyme borreliosis as a rare presentation of unilateral vision loss. BMJ Case Rep. 2016; 2016: bcr2016215307
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854126/ - Alison W. Rebman;Ting Yang;John N. Aucott;Erica A. Mihm;Sheila K. West. Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease. Translational Vision Science & Technology March 2021, Vol.10, 27
doi:https://doi.org/10.1167/tvst.10.3.27 - Paolo Mora and Arturo Carta Int J Med Sci. 2009; 6(3): 124–125. Ocular manifestations of Lyme borreliosis in Europe.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659482/ - R L Lesser. Ocular manifestations of Lyme disease The American Journal of MedicineVolume 98, Issue 4, Supplement 1,24 April 1995, Pages 60S-62S
https://pubmed.ncbi.nlm.nih.gov/7726193/ - B Biziorek1, Z Zagórski, D Jedrzejewski, D Haszcz Clinical manifestation and diagnosis of ocular borreliosis Klinika Oczna 99(2): 129-1321997
https://pubmed.ncbi.nlm.nih.gov/9379664/ - G W Zaidman The ocular manifestations of Lyme disease. Int Ophthalmol Clin. 1997 Spring;37(2):13-28.
https://pubmed.ncbi.nlm.nih.gov/9269595/ - Pinky Jha, Sophie G Rodrigues Pereira, Abhishek Thakur, Gurdeep Jhaj, Sanjay Bhandari
A Case of Optic Neuritis Secondary to Lyme Disease WMJ 2018 Jun;117(2):83-87.
https://pubmed.ncbi.nlm.nih.gov/30048578/ - Saraniya Sathiamoorthi ,Wendy M Smith The eye and tick-borne disease in the United States Curr Opin Ophthalmol 2016 Nov;27(6):530-537.
https://pubmed.ncbi.nlm.nih.gov/27585218/
DAPSONE
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